ARMADiLLO stands for “Antigen Receptor Mutation Analyzer for Detection of Low-Likelihood Occurrences” and is used for calculating the probability of amino acid mutations of antibody sequence. ARMADiLLO identifies improbable antibody mutations that are no routinely targeted by the somatic hypermutation machinery during B cell maturation.

The ARMADiLLO website can be found at:

Online Website

Features

• The singularity container takes antibody sequences and calculates the UCA
• The UCA sequences are matured in ARMADiLLO by subjecting them to several rounds of mutation
• The resulting mutated sequences are then used to calculate the probability of each mutation in the antibody

Table of Context

• Science
  • Antibody Maturation
  • Unmutated Common Ancestor Identification
• Installation
  • ARMADiLLO
    • Using Singularity
    • From Source
  • UCA generation
    • Cloanalyst
    • Partis
• Using ARMADiLLO
  • Singularity Container
    • Note
  • ARMADiLLO
  • Example Commands
    • Container Pipeline
    • Note
    • ARMADiLLO
      • Within Container
      • Stand Alone
    • Cloanalyst (Container)
    • Partis (Container)
• ARMADiLLO Output
  • Print to Screen
  • Results Files
  • HTML Style Files
• Troubleshooting
  • Installation
    • Cannot find Boost Libraries
    • Container is not Recognized
  • Running
    • Using a user generated UCA
    • No output generated
    • Cannot find sequence file

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Wiehe K., Bradley T., Meyerhoff R.R., Hart C. Williams W.B., Easterhoff D., Faison W.J., Kepler T.B., Saunders K.O., Alam S.M., Bonsignori M. and Haynes B.F. (2018) Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. Cell Host & Microbe. 23(6):759-765.